Certain lubricants containing the ingredient chlorhexidine

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In 2007 it was demonstrated that certain lubricants can cause significant damage to the rectal tissue of human study participants major shedding of cells from tissue samples biopsied 60 to 90 minutes after lubricant application was observed. Certain lubricants containing the ingredient chlorhexidine, an antibacterial agent dog dildo, has been shown to kill three species of Lactobacillus and has been shown to unbalance the natural flora in the vagina, which might lead to infections such as bacterial vaginosis. Lubricants with osmolalities closer to that of the body, such as agar based lubes, did not damage the tissue samples or boost HIV infection rates.

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